Walter Jones: Jones entered the bye with hip and back problems and exited the by with hip and back problems. He was listed as "probable" in weeks 3 and 5 and played against the New York Giants. Right defensive end Matthias Kiwanuka sacked Seneca Wallace and hit Matt Hasselbeck. Jones was listed as "team decision" and "probable" for week 6 with something described as "not injury related". After allowing two sacks by DeMarcus Ware, Jones left with a hyperextended knee in week 13. It was the last game he would play before being put on injured reserve. Jones underwent microfracture knee surgery December 11, 2008. A procedure described as "delicate" by the Seattle Time Jose Miguel Romero and to a "non-weight bearing" part of the knee by Mike Holmgren. Walter Jones was able to get into a football stance June 2, 2009. A development that was spun as encouraging. The team expects Jones ready for the 2009 season.

Sean Locklear: Locklear sprained his left knee in week 2 of the preseason against the Chicago Bears. He missed the remainder of the preseason. He was out for the first two weeks of the regular season and limited to two plays in a reserve role against St. Louis. That week he fully participated in practice. Locklear started at right tackle in week 5. He finished week 13 at left tackle and then played left tackled in weeks 14 and 15. He dislocated his toe in the final play of week 15 and was placed on injured reserve.

Kyle Williams: Williams suffered a concussion in week 17 and missed the second half.

Ray Willis: Willis was fully healthy in 2008 after battling a knee injury in 2007. He started 10 games and appeared in all 16.