The Seahawks, in my mind, have but two legitimately viable fantasy football players: Marshawn Lynch and Russell Wilson. My advice to you this week? If you've got Lynch, by all means start him - he's a RB1 in any format. If you've got Wilson as your main quarterback, he'll be a middling play, most likely.
By traditional stats, Carolina finished 14th in the league last year in rush yards allowed per game with 110 - and their 4.2 YPC allowed was 13th in the league. They gave up 11 touchdowns on the ground, which was good for 12th fewest in the NFL. Not elite, by any means, but not bad either. By Football Outsiders DVOA, Carolina finished 11th in rush defense. So, Carolina can defend the run and the quarterback of their run defense is Luke Kuechly, a budding superstar. Further, they've added Kawann Short and Star Lotulelei to the interior line, so things could get harder for a Seattle team that rushed for 2.8 yards per carry on 35 carries last year in a Week 5 matchup.
Still, Seattle is liable to run the ball more than any other team in the NFL, and from everything we've heard, Marshawn Lynch is healthy, fresh, and likely to be a major focal point on Sunday. Start him, and hope that Lotulelei and Short have a welcome to the NFL type of game (ie, get run over).
The Panthers gave up 223 yards per game in 2012 (good for 13th in the NFL) and their pass DVOA finished 12th. This was (is) a good defense, but we really have yet to see what Wilson can do after a full offseason of prep and some more time getting on the same page as his receivers. If he can build on the way he played late in the year and in the Playoffs in 2012, the sky is the limit (of course, considering that the Seahawks implement a low-volume passing offense.) Wilson did finish the year with 26 passing touchdowns and four rushing touchdowns though, and will hopefully eclipse those marks in 2013. He's a solid play in any two-quarterback league and potentially solid even in one-quarterback leagues.
After Lynch and Wilson, though, things get more muddled. Even if we're talking about 12- or 16- team leagues, Sidney Rice, Golden Tate, and Zach Miller are borderline plays. In a low-volume, spread the love passing attack, you really just never know what you're going to get from any of these three receivers, so ultimately you're going to be taking your chances starting them. Regardless, it's looking like all of Seattle's major fantasy players (sans Percy Harvin) are healthy enough to play heading into Week 1.